Transformation that occurs in a central place of the molecule (e.g. scaffold) can be loaded by first selecting either the Double or Triple Cuts tab in the Query panel.
In the current version of the application, the way to select the fragment is different compared to single-cut transformation. We are working on making it the same.
Until then, you need to do as follows (you can use the examples bonds highlighted in the screenshot bellow):
- Click on the first bond
- Click on the second bond; the existing pair(s) should then be loaded in the main canvas.
You should end up with the following:
Missing pairs
MMPs does not necessarily exist between every combination of bonds highlighted in green. Once you select the first bond, only the bonds that are compatible (generating a MMPs) with the first one will be available for selection.